【Technical News】Congratulations to our technical team on successfully delivering the following CMO project to our foreign client

Product 1:

【1】Product Backgroud

【2】Technical data

✓ Purity can reach more than 98%

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1.Pharmaceutical intermediates: Used for the synthesis of fluorine/brominated heterocyclic compounds, they may be applied in the development of anti-tumor or anti-infective drugs.

2.Materials Science: As a modified monomer for liquid crystal or polymer materials

Product 2:

【1】Product Backgroud

【2】Technical data

✓ Purity can reach more than 98%

✓ Purity can be detected by HPLC (C18 column, methanol/water gradient), and molecular weight can be verified by mass spectrometry (ESI-MS)

✓ Benzo [B] thiophene skeleton (containing 7-fluorine, 4-bromine substitutions);2-position linked ethyl carbamate (-NHCOOEt);3-cyano group (-CN

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1.Pharmaceutical intermediates:

✓ It is used for the synthesis of kinase inhibitors or anti-tumor compounds (the benzothiophene skeleton is commonly found in targeted drug design).

✓ The introduction of fluorine/bromine/cyano groups may enhance biological activity or regulate metabolic stability.

2.Materials Science: As a modification unit for organic semiconductors or fluorescent materials

Product 3:

【1】Product Backgroud

【2】Technical data

✓ Purity can reach more than 98%

✓ Benzo [B] thiophene skeleton: 7-position fluorine, 4-position bromine substitution, 3-position cyano modification;Protecting group: The 2-position amino group is protected by tert-butoxycarbonyl (Boc), enhancing stability.

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1.Pharmaceutical research and development

✓ As a key intermediate of kinase inhibitors (such as EGFR and VEGFR), the Boc protecting group facilitates subsequent deprotection derivatization.

✓ The synergistic effect of fluorine/bromine/cyano groups may optimize the metabolic characteristics of drugs (such as enhancing lipophilicity or targeting).

2.Organic synthesis: Used for constructing complex heterocyclic systems (such as thiophene pyridine compounds)

Product 4:

【1】Product Backgroud

【2】Technical data

✓ Purity can reach more than 98%

✓ Benzo [B] thiophene core: 7-position fluorine, 3-position cyano, 4-position borate ester (pinazol borate, a key precursor for Suzuki coupling);Boc protecting group: The 2-position amino group is protected by tert-butoxycarbonyl (Boc), enhancing stability and the flexibility of subsequent deprotection

【3】Technological advantage

✓ Suitable for gram to kg magnification

✓ The synthesis process is mature

【4】Commercial application

1.Suzuki-Miyaura coupling: As a key borate ester precursor, it is coupled with aryl/heteroaryl halides to construct complex drug molecules (such as kinase inhibitors).

2.Medicinal Chemistry: The benzothiophene skeleton is commonly used in the design of anti-tumor drugs (such as PARP inhibitors) and anti-inflammatory drugs. Fluorine/cyan modification can optimize the pharmacokinetic properties