(-)-Huperzine A（102518-79-6）

Huperzine A, a natural alkaloid extracted from the traditional Chinese medicine Huperzia, is a powerful, reversible and highly selective second-generation acetylcholinesterase inhibitor. It is a yellowish to white crystalline powder, easily soluble in chloroform, soluble in methanol, ethanol, and slightly soluble in water. It has high fat-solubility, small molecular weight, and can well penetrate the blood-brain barrier, After entering the center, it is mainly distributed in the frontal lobe, temporal lobe, hippocampus and other brain areas closely related to learning and memory, which have a strong inhibitory effect on acetylcholinesterase (AchE) at low doses, and significantly increase the content of acetylcholine (Ach) in the synaptic space of the distributed area, thus enhancing the excitatory conduction of neurons, strengthening the excitatory effect of learning and memory brain areas, and improving cognitive function Enhance memory retention and promote memory reproduction. It is currently the most successful drug developed in China to treat Alzheimer's disease (Alzheimer's disease).