GinkgolideB（15291-77-7）

Ginkgolide B (CAS: 15291-77-7), with the molecular formula C₂₀H₂₄O₁₀ and molecular weight of 424.40, is a high-purity diterpene lactone monomer purified from the dried leaves and roots of Ginkgo biloba. As the most valuable and well-researched active monomer of ginkgo ingredients, it serves as the most potent natural antagonist of platelet-activating factor (PAF). Different from compound ginkgo extracts, Ginkgolide B is a single active plant monomer with fixed molecular structure and definite pharmacological targets. Possessing excellent neuroprotection, anticoagulation, anti-inflammation and antioxidant capabilities, it has become an indispensable core raw material for cardiovascular drugs, nerve repair preparations, high-end health supplements and biomedical scientific research. With the rapid development of natural monomer pharmaceutical technology, Ginkgolide B has maintained steady demand growth and huge application potential in the global high-end pharmaceutical market.

In terms of physical and chemical properties, Ginkgolide B appears as white crystalline fine powder without peculiar odor. It is soluble in organic solvents such as methanol, ethanol and ethyl acetate, slightly soluble in water, and almost insoluble in low-polarity solvents. The melting point reaches about 280℃, and the compound decomposes at excessive high temperature. It maintains stable physicochemical properties under normal temperature and pressure. Nevertheless, this monomer is sensitive to strong light, high temperature and humidity. Long-term improper storage will cause oxidative deterioration and activity attenuation. It also needs to be isolated from strong alkali and oxidants to prevent molecular structural damage. The recommended storage condition is sealed, light-proof and low-temperature storage at -20℃, which can effectively maintain monomer purity and biological activity, fully meeting pharmaceutical-grade and research-grade raw material specifications.

In terms of production technology, high-quality dried ginkgo leaves are selected as raw materials. The complete preparation process adopts integrated low-temperature extraction and multi-stage chromatographic purification technology, including raw material preprocessing, low-temperature ethanol extraction, vacuum concentration, macroporous resin enrichment, solvent extraction, HPLC separation, recrystallization refining and aseptic packaging. The whole process adopts pure physical purification methods without harmful chemical residues. The low-temperature processing mode completely protects the complete molecular structure of diterpene lactones. Impurities such as flavonoids, polysaccharides and heterologous lactones are accurately removed to obtain high-purity Ginkgolide B. We can provide customized products with purity above 98%. The finished products feature low impurity content and negligible batch difference, suitable for new drug development, pharmaceutical formulation and precision pharmacological experiments.

Ginkgolide B has precise and diverse biological activities. Firstly, it antagonizes platelet activating factors to inhibit abnormal platelet aggregation, unblock microcirculation and prevent thrombosis efficiently. Secondly, it penetrates the blood-brain barrier to repair damaged neurons and relieve cerebral ischemic injury, presenting outstanding neuroprotective effects. Thirdly, it eliminates excess free radicals and inhibits the release of inflammatory factors to relieve chronic inflammation and delay cell aging. Fourthly, it inhibits abnormal cell apoptosis and regulates human metabolism, which can be applied to the development of various chronic disease maintenance products. Its mild performance and high biological safety make it superior to many synthetic chemical monomers.

This product is mainly applied in high-end biomedical fields. In the pharmaceutical industry, it is used for the research and production of cardiovascular raw materials and neuroprotective targeted drugs. In the health product industry, it is added into high-end dietary supplements for blood vessel and brain health care. In scientific research, it is widely used as a standard reference substance for natural product identification and pharmacological mechanism research.

With the increasing number of sub-health people suffering from cardiovascular diseases worldwide, high-purity plant monomers have gradually become the mainstream of pharmaceutical research instead of compound extracts. Relying on definite molecular structure, targeted pharmacological effects and unique natural advantages, Ginkgolide B enjoys booming market demand. With the continuous upgrading of purification technology and in-depth pharmacological research, it will occupy a more important position in the global cardiovascular medicine and high-end health industries, possessing promising long-term development prospects.