GinkgolideC (CAS:15291-76-6)

Ginkgolide C (CAS: 15291-76-6) is a high-value natural diterpene lactone monomer isolated and purified from dried Ginkgo biloba leaves. With a definite molecular formula of C₂₀H₂₄O₁₁, it serves as one of the core signature active ingredients of ginkgo leaves. Different from compound ginkgo extracts, Ginkgolide C is a single-structured plant monomer with higher biological activity and accurate pharmacological targeting. As a natural platelet-activating factor (PAF) antagonist, it complements Ginkgolide A and B and exhibits unique advantages in neuroprotection, anti-inflammation, antioxidation and microcirculation improvement. It is widely recognized as an essential raw material for cardiovascular pharmaceuticals, nerve repair preparations, functional health supplements and biomedical research. With the rapid development of the global natural monomer pharmaceutical industry, high-purity plant monomers have gradually replaced compound extracts, greatly driving the market demand of Ginkgolide C.

In terms of physical and chemical properties, Ginkgolide C appears as pure white crystalline fine powder without pungent odor. It is soluble in organic solvents such as methanol, ethanol and ethyl acetate, slightly soluble in water, and insoluble in weak-polarity solvents. The melting point ranges from 275℃ to 278℃, and thermal decomposition will occur under excessive high temperature. Although it maintains stable properties under conventional sealed storage, the monomer is sensitive to strong light, humidity and high temperature. Long-term improper storage will cause oxidation and activity loss. Meanwhile, it should be kept away from strong alkali and oxidants to prevent structural damage. The recommended storage condition is sealed, light-proof and low-temperature storage at -20℃ to maintain stable purity and biological activity, meeting pharmaceutical-grade and research-grade industrial standards.

In terms of production technology, high-quality dried ginkgo leaves are selected as raw materials. We adopt an integrated preparation technology combining low-temperature extraction and multi-stage chromatographic purification. The complete procedures include raw material preprocessing, low-temperature ethanol extraction, vacuum concentration, macroporous resin enrichment, solvent impurity removal, HPLC separation, recrystallization refining and aseptic packaging. Adopting pure physical purification technology without toxic reagent residues, the process completely protects the original molecular structure of diterpene lactone. Impurities such as chlorophyll, polysaccharides and heterologous lactone isomers are thoroughly removed. We can provide customized products with purity above 98%. The finished products feature ultra-low impurity content and negligible batch difference, suitable for laboratory sample testing, pilot production and large-scale industrial manufacturing.

Ginkgolide C possesses diverse and powerful biological activities. Firstly, it effectively antagonizes PAF to inhibit abnormal platelet aggregation, unblock microcirculation and prevent thrombosis. Secondly, it penetrates the blood-brain barrier to repair damaged neurons and relieve cerebral ischemic injury. Thirdly, it eliminates redundant free radicals and suppresses inflammatory factors to alleviate chronic inflammation and delay cell aging. Fourthly, it assists in regulating lipid metabolism and enhancing body immunity, which can be applied to the development of various chronic health maintenance products. Its natural mild characteristics make it safer than synthetic chemical monomers.

Its application scenarios are concentrated in high-end industries. In the pharmaceutical industry, it is used for the research and production of cardiovascular APIs and neuroprotective targeted drugs. In the health product industry, it is added into premium dietary supplements for blood vessel and brain function regulation. In scientific research, it is adopted as a standard reference substance for natural product identification and pharmacological experiments of lactone compounds.

With the continuous growth of sub-health groups worldwide, cardiovascular and neurological health problems have become increasingly common. High-purity plant active monomers have become the mainstream of the global health industry. Relying on definite molecular structure, unique pharmacological activity and natural safety, Ginkgolide C shows irreplaceable application value in pharmaceuticals, scientific research and health care fields. Supported by mature purification technology and strict quality control system, the product has enormous development potential in the global market.