【Technical News】Congratulations to our technical team on the successful delivery of the following synthetic technology projects to our foreign customers

Product 1:

【1】Product Backgroud

【2】Technical data

√ Pyrropyrimidine core + bromine substitution site (C4)

√ Piperidine ring N-methylation + di-tert-butyl ester protecting group

√ Purity can reach more than 95%

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

Antitumor drug development: synthetic precursors of JAK/STAT signaling pathway inhibitors

Product 2：

【1】Product Backgroud

【2】Technical data

√ Sulfur heterocyclic butane skeleton (4-membered ring tension structure)

√ The dimethylphosphine oxide group (with enhanced polarity of the P=O bond)

√ Amino site (pKa≈9.5, protonated)

√ Purity can reach more than 99%

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1. Pharmaceutical intermediates

Used for constructing phosphorus-containing anti-tumor drugs (such as PARP inhibitor analogues)

2. Materials Science

Flame retardant modification: Cross-linking of amino groups with epoxy resin (LOI value increased to 32%)

Lithium battery electrolyte additive: Inhibits side reactions of SEI film (Extends cycle life by 20%

3. Asymmetric catalysis

Chiral ligand synthesis: Construction of P, N-bidentate ligands with BINOL derivatives

Product 3

【1】Product Backgroud

【2】Technical data

√ Pyridine Bridges the dioxazoline skeleton

√ Chiral center: (4S) -tert-butyl configuration ([α]²⁵D = -45°±2, c=1 in CHCl₃)

√ Purity can reach more than 98%

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1.Asymmetric catalytic ligands

Copper catalysis: used for alkynes - azide cycloaddition (CuAAC), enantioselectivity > 99% ee

Palladium catalysis: Accelerated transmetallization step in Suzuki coupling (TON up to 10⁵)

2. Materials Science

Rare earth metal complex luminescent materials (Eu³⁺ complex quantum yield 38%)

Self-assembled supramolecular structure (STM shows ordered two-dimensional network arrangement)

Product 4

【1】Product Backgroud

【2】Technical data

√ Fused ring system: The [2,1-b] fused ring structure of pyrimidine and benzothiazole

√ Steric hindrance: 1, 3-double upright bond conformation of isopropyl and phenyl (DFT calculated energy barrier ΔG=12.3 kcal/mol)

√ Purity can reach more than 99%

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1. Biological activity and medical applications

√ Targeted action mechanism

5-HT₃ receptor antagonist: IC₅₀=28 nM (control Ondansetron IC₅₀=42 nM)

Anti-inflammatory activity: Inhibits the NF-κB pathway (TNF-α in the LPS model is reduced by 62%)

√ Preclinical advantages

The blood-brain barrier penetration rate (LogBB=0.15) is superior to that of similar structures

The stability of liver microsomes (t₁/₂=4.7 h) met the requirements for oral administration

2. Potential in materials science

√ Optical performance

Fluorescence quantum yield Φ=0.45 (λₑₘ=480 nm in ethanol)

Circular dichroic signal: The Cotton effect at 265 nm is Δε=+12.3