Methyl 2-acetylamino-3-chloropropionate(R)-2-乙酰氨基-3-氯丙酸甲酯(CAS:18635-38-6)

Methyl (R)-2-acetamido-3-chloropropanoate (CAS: 18635-38-6) is a high-end custom synthetic chiral amino acid derivative and a professional pharmaceutical intermediate belonging to fine chemicals. Prepared by advanced organic synthesis technology, this compound features a unique right-handed chiral configuration and stable molecular structure. It serves as an indispensable basic raw material targeted for targeted drug research, asymmetric organic synthesis and biochemical experiments. Different from general chemical raw materials, this customized chemical has high technical barriers in synthesis, purification and quality inspection. Characterized by high chiral purity, low impurity residue and stable stereoscopic configuration, it provides reliable material support for pharmaceutical enterprises, university laboratories and biopharmaceutical research institutions, widely used for manufacturing anti-infective drugs, anti-tumor intermediates and new biological preparations.

In terms of physical and chemical properties, the product appears as colorless or light yellow transparent liquid at room temperature without pungent odor. It is easily soluble in organic solvents such as ethanol, dichloromethane and ethyl acetate, slightly soluble in water, compatible with most organic synthesis systems and liquid phase detection environments. The compound presents strong chemical inertness under normal temperature and pressure, and will not decompose or racemize spontaneously. However, its amide groups and active chlorine atoms are sensitive to strong alkali, strong oxidants and ultra-high temperature. Improper storage will cause hydrolysis and racemization, reducing chiral purity. It shall be stored in sealed and light-proof containers at 2-8℃, kept away from acid-base substances and heat sources to maintain stable physicochemical properties, complying with international fine pharmaceutical intermediate standards.

In terms of production technology, this product adopts exclusive fully customized total synthesis process. The complete manufacturing procedures include raw material proportioning, low-temperature chiral catalytic synthesis, asymmetric induction reaction, multi-stage extraction, vacuum distillation, chiral chromatographic resolution, high-precision purification and sealed filling. Adopting closed-loop synthesis system, we take high-purity propionic acid derivatives as starting materials and use chiral catalysts to directionally synthesize single R-type isomers, eliminating racemic impurities from the source. We can provide products with purity ranging from 95% to 99.9% according to customer demands. The finished products have ultra-low solvent residue and zero racemization, suitable for laboratory research, pilot test and large-scale industrial pharmaceutical production.

This chiral intermediate is mainly used to build molecular skeletons for high-end chiral drugs. Its acetamido groups and chlorine-substituted functional groups can participate in various organic reactions to facilitate molecular modification and structural optimization. Compared with similar isomers, the R-type configuration of our product has better biocompatibility and controllable reaction activity, which can reduce side reactions during drug synthesis, improve finished product yield and effectively cut down the R&D cost of new drugs. In addition, our products feature negligible batch difference to eliminate raw material adaptation problems in the whole production chain.

It is mainly applied in three high-end fields: pharmaceutical industry, chemical synthesis and scientific research. In the pharmaceutical field, it is used for synthesizing anti-infective drugs, targeted anti-cancer drugs and amino acid active pharmaceutical ingredients. In the fine chemical industry, it acts as a chiral building block for asymmetric synthesis and derivative development. In scientific research, it is widely used for chiral chemistry experiments and new drug research in universities and research institutes worldwide.

With the rapid development of the global biomedical industry, chiral drugs have gradually replaced traditional chemical drugs due to low side effects and high targeting performance, greatly boosting the market demand for customized chiral intermediates. As a scarce high-end chiral building block, Methyl (R)-2-acetamido-3-chloropropanoate has irreplaceable application value in frontier drug development. Supported by mature synthesis technology, strict quality control system and flexible supply mode, this product possesses strong core competitiveness and huge market potential in the global pharmaceutical intermediate industry.