Indapamide（CAS·：26807-65-8）

Indapamide (CAS: 26807-65-8) is a long-acting sulfonamide-based antihypertensive and diuretic active pharmaceutical ingredient widely applied in the global pharmaceutical industry. With a molecular formula of C₁₆H₁₆ClN₃O₃S and a molecular weight of 365.84, this compound serves as a critical pharmaceutical intermediate and raw material for the clinical treatment of hypertension and edema-related diseases. The product appears as pure white crystalline powder with no peculiar odor, featuring stable physical and chemical properties, excellent moisture resistance and oxidation resistance. It is highly adaptable to long-term storage and large-scale industrial production. Adopting sophisticated refining and purification technologies, our Indapamide reaches an HPLC purity of over 99% with extremely low residual impurities, fully complying with international pharmaceutical-grade standards.

Different from traditional diuretic antihypertensive materials that rely on a single mechanism, Indapamide possesses dual pharmacological effects, including efficient sodium diuresis and peripheral vasodilation. It can effectively inhibit the reabsorption of sodium and chloride ions in renal tubules, accelerate the excretion of excess water and sodium in the body, relieve systemic water-sodium retention, and reduce cardiac burden. Meanwhile, it relaxes peripheral vascular smooth muscles, decreases peripheral vascular resistance, and achieves stable and long-lasting antihypertensive effects. Its mild action mechanism avoids sharp blood pressure fluctuations, ensuring high safety and low side effects for long-term clinical medication.

Superior to common thiazide diuretics, Indapamide shows weak diuretic activity but outstanding antihypertensive performance. It is the preferred raw material for the preparation of clinical drugs for essential hypertension and senile hypertension, and it is also widely used in adjuvant treatment of edema and water-sodium retention caused by heart failure. In terms of production technology, the product undergoes precise chemical synthesis, multiple solvent extraction, recrystallization purification and high-performance liquid chromatography refinement. The whole production process is strictly controlled to remove residual intermediates, harmful substances and miscellaneous impurities, ensuring high purity, uniformity and batch stability.

This product covers a wide range of application scenarios. It is not only the core raw material for pharmaceutical factories to produce Indapamide tablets and capsules, but also a standard reference substance commonly used in medical research institutions, university laboratories and testing institutions for pharmacological experiments, drug content determination and new drug development. In terms of supply service, we support diversified packaging specifications, including small laboratory packages of 10mg and 100mg for scientific research, as well as kilogram and ton-level bulk supply for industrial mass production. All products are delivered with complete COA certificates, HPLC chromatograms, MS mass spectrometry data and full quality documents. With sufficient spot inventory and efficient delivery, we provide stable long-term high-quality raw material supply for global pharmaceutical enterprises and scientific research institutions.