Shikalkin(54952-43-1)

Biological activity: Shikonin (nchusin, Anchusaacid, AlkannaRed, C.I.75535, Isoarnebin4, NSC252844) is an effective and specific inhibitor of PyruvatekinaseM2 (PKM2). It is the main ingredient of Arnebia. Arnebia is a Chinese herbal medicine with a variety of biological activities. In the cell fluorescence quenching test, Shikonin is also an inhibitor of TMEM16A chloride channel. Shikonin inhibits tumornecrosisfactor- α (TNF- α) It plays an anti-inflammatory role and can prevent nuclearfactor by inhibiting proteasome- κ B(NF- κ B) Activation of signal pathway.