Verapamil(CAS:52-53-9)

Verapamil, CAS 52-53-9, is a classic phenylalkylamine calcium channel blocker and core clinical cardiovascular API. It selectively blocks calcium channels on myocardial and vascular smooth muscle cell membranes, inhibits calcium influx, relaxes vascular smooth muscles, dilates peripheral blood vessels and reduces vascular resistance. Meanwhile, it slows atrioventricular conduction, weakens myocardial contraction and decreases myocardial oxygen consumption. With triple pharmacological effects of antihypertension, anti-angina and anti-arrhythmia, Verapamil is widely applied in the treatment of hypertension, variant angina, stable angina and paroxysmal supraventricular tachycardia, serving as an essential raw material for cardiovascular drug preparation.