Diosmin(CAS:520-27-4)

Diosmin (CAS: 520-27-4), chemically named 3'',5,7-Trihydroxy-4''-methoxyflavone 7-rutinoside, also known as diosmine or barosmin, has the chemical formula C₂₈H₃₂O₁₅ and a molecular weight of 608.55. It is a semi-synthetic flavonoid compound derived from the modified processing of extracts from citrus peels (such as lemons and bergamots). It also naturally exists in the roots of Zanthoxylum nitidum and the fruits of bergamots. As a functional raw material with both medicinal value and health benefits, it is widely used in the fields of medicine and dietary supplements. With clear pharmacological activities and good safety, it has become one of the core raw materials in the field of venous health care.

In terms of physical and chemical properties, Diosmin appears as a greyish-yellow to pale yellow crystalline powder, odorless, tasteless and non-irritating, with stable overall physical and chemical properties. Its solubility has obvious characteristics: it is practically insoluble in water and ethanol, slightly soluble in methanol, easily soluble in dimethyl sulfoxide (DMSO), and very slightly soluble in dilute alkaline solutions. This solubility feature requires the use of a suitable solvent system for dissolution and compounding in pharmaceutical preparation processing. The melting point of this product is 277-278℃, the boiling point is about 926.8℃, and the density is about 1.68g/cm³. It has good stability in a normal temperature and dry environment, but is relatively sensitive to strong light, high temperature and high humidity. Long-term exposure is prone to oxidative inactivation. Therefore, it must be stored in sealed, light-proof, dry and low-temperature (2-8℃) conditions to avoid moisture absorption, caking or component degradation, ensuring the purity and activity stability of the product.

In terms of production process, Diosmin is mainly prepared by a semi-synthetic process. Using flavonoid components (such as hesperidin) from natural citrus peel extracts as raw materials, its molecular structure is optimized through specific chemical modification or enzymatic catalysis to enhance its pharmacological activity and processing adaptability. The production process mainly includes precision steps such as raw material pretreatment, extraction and purification, modification reaction, refining and crystallization, drying and packaging, which fully complies with green chemical standards without producing toxic or harmful substances, and the production process is mature and controllable. At present, industrial production can stably produce high-purity Diosmin products with a purity of more than 95% and extremely low impurity content, meeting the relevant industry standards of pharmaceutical grade and dietary supplement grade, and can meet the needs of large-scale applications.

The core value of Diosmin lies in its excellent vascular protective effect. As a powerful vascular protectant and venous tone enhancer, its pharmacological activities have been verified by a large number of clinical experiments. It is highly safe with mild side effects. Only a few people may experience slight gastrointestinal reactions or autonomic nervous disorders, which do not require interruption of treatment and are suitable for long-term use. Its core functions are concentrated in improving venous function, regulating microcirculation, and enhancing vascular toughness: first, it can reduce venous distensibility, reduce venous stasis, enhance venous tone, effectively relieve symptoms such as limb heaviness, numbness, pain, and edema caused by venous insufficiency, and has an auxiliary improvement effect on thrombophlebitis, deep vein thrombosis syndrome, etc.; second, it can regulate the permeability of capillary walls, enhance capillary resistance, improve microcirculation disorders, and reduce tissue edema and congestion.

In addition, Diosmin can also relieve symptoms related to acute hemorrhoid attacks, such as anal moisture, itching, pain, and hematochezia, assist in improving hemorrhoidal varicose veins, and is a common raw material for the auxiliary treatment of anorectal diseases. At the same time, it also has a certain antioxidant activity, which can scavenge free radicals in the body, reduce oxidative stress damage to blood vessels, and assist in protecting cardiovascular health. Pharmacokinetic studies have shown that Diosmin is rapidly absorbed in the gastrointestinal tract, mainly excreted through feces, and a small amount of metabolites are excreted in urine in the form of glucuronic acid conjugates, with a half-life of about 11 hours and good bioavailability.

In terms of application scenarios, Diosmin is mainly concentrated in the two major fields of medicine and dietary supplements, with precise application scenarios and stable demand. In the field of medicine, it is the core raw material for preparing Diosmin tablets, capsules and other drugs. It is mainly used for the treatment of symptoms related to venous and lymphatic insufficiency and acute hemorrhoid attacks. It is a commonly used capillary protectant in clinical practice, has been included in the second-class medical insurance, and is widely used. In the field of dietary supplements, it can be used as a functional raw material to make dietary supplements for venous health and microcirculation regulation, suitable for people who sit or stand for a long time, middle-aged and elderly people, and people with anorectal discomfort, helping to maintain venous health and relieve symptoms such as limb heaviness and edema.

With the change of people's lifestyle, problems such as venous insufficiency and anorectal diseases have become increasingly common, and the demand for safe and effective vascular protective raw materials continues to rise. Diosmin has become the preferred raw material in the fields of medicine and dietary supplements due to its clear pharmacological activities, good safety and mature production process. In the future, with the deepening of research and development, its application scenarios will be further expanded, and the production process will be continuously optimized to improve product purity and output while reducing costs, further releasing market potential and providing better raw material support for the field of venous health care.