GinkgolideJ(CAS:107438-79-9)

Ginkgolide J (CAS: 107438-79-9) is a rare high-value diterpene lactone monomer purified from dried Ginkgo biloba leaves. With a molecular formula of C₂₀H₂₄O₁₁, it belongs to an indispensable member of the ginkgolide family. Compared with ordinary ginkgolide A, B and C, Ginkgolide J has lower natural content and higher research value. Different from compound ginkgo extracts, this single-component monomer features definite molecular structure and targeted pharmacological effects without redundant interfering impurities. It has become a premium special raw material widely used in neuromedicine, cardiovascular pharmacy and cell biology research. In recent years, Ginkgolide J has gained increasing popularity in global new drug development and academic research due to its unique nerve and myocardial protection characteristics.

In terms of physical and chemical properties, Ginkgolide J appears as pure white uniform crystalline powder without peculiar odor. It is soluble in organic solvents such as methanol, ethanol and ethyl acetate, slightly soluble in water, and insoluble in low-polarity solvents. The melting point ranges from 270℃ to 274℃. Although it maintains stable performance under conventional sealed conditions, the monomer is sensitive to strong light, humidity and extreme high temperature. Long-term improper storage will cause oxidation and activity degradation. In addition, it must be isolated from strong acid, strong alkali and oxidants to prevent molecular hydrolysis and structural damage. The recommended storage environment is sealed, light-proof and low-temperature refrigeration at -20℃ to maintain stable purity and biological activity, meeting pharmaceutical-grade and research-grade quality specifications.

In terms of production technology, high-quality dried ginkgo leaves are selected as raw materials. We adopt low-temperature extraction combined with preparative HPLC purification technology. The complete manufacturing process includes raw material pretreatment, low-temperature ethanol extraction, vacuum concentration, macroporous resin enrichment, solvent extraction, high-precision chromatographic separation, repeated recrystallization and aseptic packaging. The whole process adopts pure physical purification without harmful chemical residues. We accurately remove flavonoids, polysaccharides and other lactone impurities to obtain high-purity Ginkgolide J. Customized products with purity above 98% are available for sample testing, pilot research and large-scale mass production. The finished powder has ultra-low impurity content and negligible batch difference to satisfy diverse customer demands.

Ginkgolide J possesses distinctive and powerful biological activities. Firstly, it penetrates the blood-brain barrier to inhibit neuronal apoptosis and relieve cerebral ischemic damage, realizing efficient central nervous system repair. Secondly, it protects myocardial cells, alleviates myocardial ischemia injury and optimizes cardiovascular microcirculation. Thirdly, it eliminates excess free radicals and inhibits inflammatory factors to relieve chronic inflammation and delay cell aging. Fourthly, it regulates human metabolism and enhances immune activity, supporting the development of chronic disease maintenance health products. Its unique biological mechanism cannot be replaced by other ordinary ginkgolide monomers.

Its application fields are concentrated on high-end industries. In the pharmaceutical industry, it is used for the development of neurological targeted drugs, cardiovascular APIs and anti-inflammatory intermediates. In the health care industry, it is added into premium dietary supplements for brain and myocardial maintenance. In scientific research, it serves as a dedicated standard reference substance for ginkgolide isomer analysis and neuropharmacological experiments.

With the rapid development of the global biomedical industry, rare high-purity plant monomers have become the core of high-end new drug research. Relying on scarce natural resources, targeted pharmacological effects and stable physicochemical properties, Ginkgolide J has become a promising star product in the ginkgolide series. With the continuous upgrading of purification technology and in-depth pharmacological exploration, it will occupy a more important position in the global pharmaceutical and scientific research markets with enormous development potential.