Ginsenoside Re（52286-59-6）

Ginsenoside Re (CAS: 52286-59-6), with molecular formula C₄₈H₈₂O₁₈ and molecular weight of 946.15, is a typical protopanaxatriol-type ginsenoside and one of the high-content water-soluble active monomers in natural ginseng. It is widely distributed in Araliaceae plants such as ginseng, American ginseng and Panax notoginseng. With abundant natural reserves and moderate extraction cost, it has mass production advantages different from rare ginsenosides. Featuring clear structure, mild properties, diverse biological activities and high safety, Ginsenoside Re has become a benchmark raw material for basic saponin research. It is widely used in biomedicine, functional health products, cosmetics and scientific research due to its mature research in cardiovascular protection, nerve regulation, anti-inflammation and anti-oxidation.

In terms of physical and chemical properties, Ginsenoside Re is white crystalline powder with bitter taste and no peculiar smell, possessing stable physicochemical properties. It is easily soluble in organic solvents such as methanol, ethanol and n-butanol, and also soluble in water. Its water solubility is better than most ginsenosides, compatible with various water-based and alcohol-based formulas. It is not easy to deteriorate under normal temperature and dry environment, but long-term exposure to strong light, high temperature and humidity will cause oxidative discoloration and moisture agglomeration. It should be stored in sealed, light-proof, cool and dry conditions away from oxidants to maintain stable purity and biological activity.

In industrial production, Ginsenoside Re is prepared from artificially planted fresh ginseng through green purification technology combining low-temperature water extraction and alcohol dissolution. The production procedures include raw material screening, cleaning, low-temperature crushing, water extraction, vacuum concentration, alcohol precipitation, macroporous resin enrichment, HPLC refining, recrystallization and vacuum drying. Adopting pure physical purification without harmful residues, the process retains natural saponin activity efficiently. Impurities and isomers are removed through multi-stage separation technology. Industrial refined Ginsenoside Re can reach a purity of more than 98%, with pure appearance and low impurities, suitable for large-scale production and high-precision scientific research.

Ginsenoside Re has mild and rich biological activities, mainly including cardiovascular protection, anti-oxidation, anti-inflammation and nerve soothing. For cardiovascular care, it regulates vascular permeability, improves blood circulation and maintains cardiovascular stability. It can scavenge excess free radicals, inhibit lipid peroxidation and reduce oxidative damage to delay cell aging. Its anti-inflammatory effect inhibits the secretion of inflammatory factors and relieves mild inflammation. In addition, it soothes the central nervous system and alleviates mental fatigue and irritability. With mild effect and high compatibility, it is suitable for long-term conditioning.

Ginsenoside Re has a wide range of universal applications. In the pharmaceutical field, it serves as a pharmaceutical intermediate for the research of cardiovascular and anti-inflammatory drugs with complete pharmacological research system. In the health product industry, it is compounded with other saponins to make dietary supplements for daily anti-oxidation and physical conditioning. In cosmetics, it is added into repair formulas to improve skin redness and dullness. In scientific research, it is widely used as a standard reference substance for saponin detection and pharmacological experiments.

With the standardized development of natural plant extracts, mild, high-compatibility and low-cost plant active raw materials are increasingly popular. Benefiting from high natural content, mature extraction technology, comprehensive efficacy and high safety, Ginsenoside Re has achieved rising market coverage. In the future, the purification technology will be continuously optimized, and water solubility modification will further expand its application scope. With stable quality and diverse activities, Ginsenoside Re will continue to develop in health care, biomedicine and cosmetics, becoming a basic core raw material with high universality and cost performance among ginsenosides.