LicochalconeC(144506-14-9)

Biological activity: Licochalcone C can inhibit α- Glucosidase（ α- Glossidase), which is α- The IC50 values of glucosidase and protein tyrosine phosphatase 1B were<100 nM and 92.43 respectively μ M。

Target: IC50:<100nM（ α- glucosidase),92.43 μ M(PTP1B).

In vitro study: LicochalconeCcouldinhibit α- glucosidase,withIC50sof<100nMand92.43 μ Mfor α- glucosidaseandPTP1B,respectively.ItisalsoindicatedthatLicochalconeCinducesT24cellapoptosisinaconcentration‑dependentmanner.LicochalconeCtreatmentreducChemicalbookesthelevelsoftheanti‑apoptoticmRNAs(Bcl-2,Bcl-wandBcl-XL)andincreasesexpressionofthepro-apoptoticmRNAs(BaxandBim).TheBcl-2familyinhibitor(ABT-737)reducesapoptosisinducedbylicochalconeCinT24cells.

Chemical properties: yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from licorice roots.

Usage Glycyrrhizin chalcone C has the functions of anti-ulcer, anti-bacterial, anti-inflammatory, reducing blood lipids, scavenging free radicals and anti-oxidation.

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