Oridonin（CAS:28957-04-2)

Oridonin (CAS: 28957-04-2) is a natural ent-kaurane tetracyclic diterpenoid monomer isolated and purified from Isodon rubescens. It is the most representative and highest active medicinal ingredient of Isodon rubescens. With a unique tetracyclic diterpenoid molecular structure, it possesses stronger pharmacological activity than conventional plant extracts. Purified Oridonin features high purity, precise action targets and clear pharmacological mechanism. It is widely applied in biomedical new drug research, precision scientific experiments and high-end pharmaceutical intermediates, becoming a high-value natural plant monomer in modern pharmaceutical research.

In terms of physical and chemical properties, Oridonin appears as colorless or pale yellow needle-shaped crystal powder with slight bitter taste and stable basic properties. It is easily soluble in organic solvents such as methanol, ethanol and acetone, slightly soluble in chloroform, and almost insoluble in water, suitable for alcohol-soluble industrial and scientific research systems. Its molecular structure is stable under sealed, dark and low-temperature storage. However, diterpenoid structures are sensitive to high temperature and strong oxidation. Long-term exposure to high temperature and humidity will cause activity attenuation and structural damage. It must be stored in sealed, light-proof, dry and low-temperature environment to maintain stable purity and biological activity, meeting pharmaceutical and research-grade standards.

In industrial production, Oridonin is prepared from high-quality Isodon rubescens through solvent extraction and multi-stage purification and recrystallization. The production procedures include raw material screening, low-temperature drying, crushing, ethanol reflux extraction, vacuum concentration, degreasing, macroporous resin enrichment, silica gel column separation, HPLC refining, recrystallization and vacuum drying. Adopting mild physical purification technology without harmful residues, the process completely protects the active diterpenoid structure. Impurities such as crude fibers, polysaccharides and miscellaneous terpenoids are strictly removed. Industrial high-purity Oridonin can reach over 98% purity with uniform crystal form and low impurities for high-end application scenarios.

Oridonin has diverse and powerful biological activities, mainly including anti-tumor, anti-inflammatory, antibacterial, antioxidant and immune regulation effects. It has broad-spectrum anti-tumor activity, which can inhibit tumor cell proliferation, migration and invasion, and induce tumor cell apoptosis with low toxicity to normal cells. It significantly inhibits the release of inflammatory factors and relieves acute and chronic inflammation. In addition, it scavenges excess free radicals to reduce oxidative damage and regulate immune function. With mild and long-lasting effects, it has excellent application safety.

Oridonin is positioned as a high-end fine pharmaceutical raw material. In the pharmaceutical field, it serves as a core intermediate for the research and development of anti-tumor and anti-inflammatory innovative drugs. In scientific research, it is widely used as standard reference substance and experimental reagent for phytochemical analysis and pharmacological research. In bioengineering, it is applied to the research and development of high-end biological preparations. With high safety and stable activity, it is also used in the formulation development of high-end functional raw materials.

With the rapid development of modern natural medicine industry, high-purity plant monomers have become the core direction of new drug research. Benefiting from its unique natural structure, powerful pharmacological activity and mature research system, Oridonin maintains steady growth in market demand. In the future, with the continuous optimization of purification technology, its industrial application scope will be further expanded. With stable quality and high research value, Oridonin will continue to play an important role in biomedicine and scientific research, becoming a benchmark product in natural plant monomer raw materials.