Naringenin(480-41-1)

Naringenin (CAS: 480-41-1), chemically named 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, has the molecular formula C₁₅H₁₂O₅ and a molecular weight of 272.25. It is a high-value natural dihydroflavone compound, mainly enriched in the peel and pulp of rutaceae citrus plants such as pomelo, grapefruit and sweet orange. As an important secondary metabolic active ingredient in citrus, Naringenin has become one of the most widely researched flavonoid monomers due to its natural source, high safety and rich biological activities. It is widely applied in pharmaceuticals, dietary supplements, cosmetics and food industry.

In terms of physical and chemical properties, Naringenin is white crystalline powder at room temperature, odorless and tasteless with stable physical and chemical characteristics. Its melting point is about 252-254℃. It is sparingly soluble in cold water, slightly soluble in hot water, and easily soluble in organic solvents such as methanol, ethanol and acetone. Naringenin is sensitive to strong light and high temperature, and it is easy to oxidize and discolor in humid and high-temperature environments. Therefore, it should be stored in sealed, dry, cool and light-proof conditions, away from oxidants to maintain stable purity and biological activity.

In industrial production, Naringenin is mainly extracted from natural citrus peel. The mature production process combines ethanol reflux extraction, ultrasonic-assisted extraction and macroporous resin purification. The production procedures include raw material pretreatment, degreasing extraction, filtration and concentration, chromatographic impurity removal, recrystallization and low-temperature drying. The whole process complies with green chemical standards without harmful residues. The purity of refined Naringenin can reach more than 98%, meeting the industrial standards of food grade, cosmetic grade and pharmaceutical intermediate grade, suitable for large-scale industrial production and laboratory research.

Naringenin possesses diverse and prominent biological activities. It has strong antioxidant capacity to scavenge excess free radicals, inhibit lipid peroxidation and reduce oxidative damage to cells. It also has excellent anti-inflammatory and bacteriostatic effects, which can inhibit the release of inflammatory factors, relieve skin redness and discomfort, and restrain the activity of harmful microorganisms. Different from other flavonoids, Naringenin has outstanding liver protection and metabolic regulation capabilities, which can assist in maintaining normal liver metabolism and regulate lipid and sugar metabolism, making it highly suitable for metabolic health products.

Naringenin has a wide range of application fields. In the pharmaceutical industry, it serves as an important pharmaceutical intermediate for the research and development of anti-inflammatory, liver-protective and metabolic regulatory drugs. In the health product industry, it is often made into dietary supplements for liver care, metabolic conditioning and anti-aging groups. In the cosmetic industry, it is added into serums, creams and repair lotions to brighten skin tone and relieve sensitivity. In the food industry, it can be used as a natural food antioxidant to replace synthetic preservatives and extend the shelf life of food.

With the continuous growth of the global natural health consumption trend, the market demand for natural plant active raw materials is steadily increasing. Benefiting from wide sources, controllable cost, definite efficacy and high safety, Naringenin enjoys rising market demand year by year. In the future, through microencapsulation and inclusion technology, its poor water solubility and low bioavailability will be improved continuously. With the rapid development of healthcare, biomedicine and high-end skin care industries, Naringenin will continue to exert important value and become a promising core product among natural functional flavonoid raw materials.